A new study found that hydroxychloroquine, adisease-modifying antirheumatic drug (DMARD)sometimes used to treatrheumatoid arthritis (RA)andlupus, does not reduce pain related toosteoarthritis (OA)of the hand, possibly ending the hope for an easy solution to a challenging problem.
Pain fromhand OAaffects an estimated 3 percent to 15 percent of adults over 60 and up to 31 percent of those over 70, making daily tasks difficult and diminishing quality of life. Increasing evidence suggests that low levels of inflammation may be an important source of pain in hand OA, at least in some people. Few medications are effective for hand OA other than traditional pain relievers, such asnonsteroidal anti-inflammatories (NSAIDs), acetaminophen and, in more intractable cases, opioids – all of which have side effects and can’t be used in certain populations. Researchers have been looking for other treatments.