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Keep up-to-date on the latestrheumatoid arthritis (RA)研究与我们的简要研究总结。
Tofacitinib Plus Methotrexate May Work As Well As Biologic
If methotrexate (MTX) alone fails to control RA, adding the oral Janus kinase (JAX) inhibitor tofacitinib (Xeljanz) may be as effective as the standard practice of adding a biologic. The JAX inhibitor belongs to the third category ofdisease-modifying antirheumatic drugs (DMARDs)called targeted DMARDs. In a study of 1,146 patients with rheumatoid arthritis that had not adequately responded to MTX alone, approximately a third were switched to tofacitinib, while the others received either tofacitinib or thebiologicadalimumab (Humira)和甲氨蝶呤。在6个月时，接受托法替尼单药治疗的患者中只有38%的患者ACR50，即50%的改善，而接受托法替尼和甲氨蝶呤治疗的患者中有46%的患者达到了这种反应。联合使用阿达木巴布和甲氨蝶呤的患者中，44%的患者获得了与tofacitnib和甲氨蝶呤组相似的改善反应。
SOURCE:The Lancet, July 2017Continue readingRA Research Briefs: Tofacitinib, Fish, Remission→
Keep up-to-date on the latestrheumatoid arthritis (RA)研究与我们的简要研究总结。
Smoking, Obesity Make RA Harder to Control
Remission in RA patientscan be harder to achieve in those who are overweight or smoke, according to a recent study. American and Canadian researchers who collected data on more than 1,100 patients receiving standard treatment for RA found that sex (being female),excess weightandsmokingwere not significantly associated with symptom severity early on. However, all three factors influenced how much symptoms improved over time. The most dramatic differences in symptoms were seen in patients who were overweight or obese and smoked, the study found.
Source: ACR/ARHP Annual Meeting, November 2016
Continue readingRA Research Briefs: Remission, Biologics, Exercise→
Keep up-to-date on the latestrheumatoid arthritis (RA)研究与我们的简要研究总结。
Obesity Reduces Odds of RA Remission
Research suggests weight may be a factor in whether people with RA will achieve disease remission. A review of studies screened a total 3,368 patient records. Canadian researchers found obese patients with RA were less likely to achieve remission or sustain remission compared to healthy-weight patients.Obesity, they reported, negatively impacts disease activityand patient-reported outcomes during therapy. Therefore, they say, interventions to reduce BMI should be investigated for the ability to improve disease outcomes.
Source: Arthritis Care & Research, January 2017
Continue readingRA Research Briefs: Remission, Surgery, Green Tea→
Biologic drugs make it possible for many people with inflammatory types of arthritis, such asrheumatoid arthritis(RA), to achieve low disease activity or remission. But because of the drugs’ cost and the potential for serious side effects, many patients don’t want to stay on them indefinitely, so researchers have been looking at whether it’s possible to taper or stop them. A new study, published recently inArthritis & Rheumatology,is adding to the growing body of research on the topic.
Continue readingStudy: Risk of Rheumatoid Arthritis Flare Triples in People Who Stop Anti-TNFs→
