An emerging class of medications called janus kinase inhibitors (JAK inhibitors, orjakinibs) is offering new hope to patients withrheumatoid arthritis(RA) who don’t find relief with other treatments.

What are Jakinibs?

Jakinibs are a new class of medication, sometimes called oral biologics. The word “biologic” is misleading, however, because jakinibs work in an entirely different way than the biologics that have been used to date. Jakinibs are small molecules that workinsidecells. Traditional biologics such as etanercept (Enbrel), adalimumab (Humira), abatacept (Orencia) and Infliximab (Remicade) block pro-inflammatory cytokines fromoutside.

Jakinibs are taken by mouth. Traditional biologics are given through infusions or injections.

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