In February, we reported on Dr. Farshid Guilak’scurrent Arthritis Foundation-funded trailblazing project, “Engineering New Biologic Therapies for Arthritis.”

Dr. Guilak’s work is published in the journalStem Cell Reports. The paper, entitled “Genome engineering of stem cells for autonomously regulated, closed-loop delivery of biologic drugs,” describes the research team’s method of engineering (reprogramming) stem cells to become “smart stem cells” that will sense inflammation and deliver biologic drugs where they are most needed. The smart stem cells-biologic drug combination is then injected into an arthritic joint.
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